Sotyktu (deucravacitinib) is used to treat moderate to severe plaque psoriasis to help improve scaling and redness and reduce thickened areas on the skin and scalp, with some patients achieving clear or almost clear skin and scalp. Sotyktu is a once-daily tablet that works by blocking a protein called tyrosine kinase 2 (TYK2); this reduces the inflammation and immune pathways responsible for plaque psoriasis. Sotyktu is a tyrosine kinase 2 (TYK2) inhibitor.
Plaque psoriasis is a chronic autoimmune skin condition that has itchy and painful patches of skin that are thickened, red, and typically covered by silvery-white scales. One of the causes of plaque psoriasis involves a protein called tyrosine kinase 2 (TYK2), which works with proteins (IL-23 and IL-17) in your immune system to cause the formation of plaque psoriasis.
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